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Article

Proteomic analysis uncovers biological diversity in molecularly defined endometrial carcinomas.

Neoplasia (New York, N.Y.) - 1 Nov 2025

Cochrane Dawn R, Negri Gian Luca, Huvila Jutta, Kalantari Forouh, Farnell David A, Mohammad Nissreen, Thompson Emily, Yang Winnie, Lum Amy, Spencer Sandra E, Riley Ryan, Jamieson Amy, Leung Samuel, Chiu Derek, Chow Christine, Lim Jamie L P, Köbel Martin, Kommoss Stefan, Kommoss Friedrich, Gilks Blake, Hoang Lien, Huntsman David G, Morin Gregg B, McAlpine Jessica N

Abstract excerpt

While endometrial cancer has an overall favorable prognosis, some patients have poor outcomes and may benefit from further refinements of the current classification systems. Molecular classification stratifies endometrial cancer patients into four prognostic subtypes: POLEmut, MMRd (mismatch repair deficient), p53abn, and NSMP (no specific molecular profile), where patients with POLEmut have the best prognosis...

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Identifiers

PMID: 40966993
DOI: 10.1016/j.neo.2025.101229
PMCID: PMC12478120

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