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Article

HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.

PLoS medicine - 1 Jul 2015

Xu Wei-Li, Pedersen Nancy L, Keller Lina, Kalpouzos Grégoria, Wang Hui-Xin, Graff Caroline, Winblad Bengt, Bäckman Lars, Fratiglioni Laura

Abstract excerpt

BACKGROUND: Research has suggested that variations within the IDE/HHEX gene region may underlie the association of type 2 diabetes with Alzheimer disease (AD). We sought to explore whether IDE genes play a role in the association of diabetes with dementia, AD, and structural brain changes using data from two community-based cohorts of older adults and a subsample with structural MRI. METHODS AND FINDINGS: The...

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Source

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Identifiers

PMID: 26173052
DOI: 10.1371/journal.pmed.1001853
PMCID: PMC4501827

Genes

IDE
HHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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