Article
Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease.
Annals of neurology - 1 Feb 2026
Gavrielatos Marios, Heckman Michael G, Soto-Beasley Alexandra I, Blumenfeld Sophia G, Hou Xu, Koga Shunsuke, Murray Melissa E, Kasanuki Koji, Ono Daisuke, Fiesel Fabienne C, Uitti Ryan J, Fields Julie A, Botha Hugo, Ramanan Vijay K, Kantarci Kejal, Lowe Val J, Jack Clifford R, Ertekin-Taner Nilufer, Gibbs J Raphael, Traynor Bryan J, Dalgard Clifton L, Savica Rodolfo, Graff-Radford Jonathan, Petersen Ronald C, Reichard R Ross, Graff-Radford Neill R, Ferman Tanis J, Boeve Bradley F, Wszolek Zbigniew K, Springer Wolfdieter, Gan-Or Ziv, Mignot Emmanuel, Scholz Sonja W, Dickson Dennis W, Ross Owen A
Abstract excerpt
OBJECTIVE: Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α-synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte antigen (HLA) gene complex. Here, we assessed whether...
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