Article
Trans-Ethnic Fine-Mapping of the Major Histocompatibility Complex Region Linked to Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2021
Naito Tatsuhiko, Satake Wataru, Ogawa Kotaro, Suzuki Ken, Hirata Jun, Foo Jia Nee, Tan Eng-King, Toda Tatsushi, Okada Yukinori
Abstract excerpt
BACKGROUND: Despite evidence for the role of human leukocyte antigen (HLA) in the genetic predisposition to Parkinson's disease (PD), the complex haplotype structure and highly polymorphic feature of the major histocompatibility complex (MHC) region has hampered a unified insight on the genetic risk of PD. In addition, a majority of the reports focused on Europeans, lacking evidence on other populations....
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