Article
Chameau (HBO1) regulates starvation resistance in Drosophila melanogaster in a temperature-dependent manner.
Life science alliance - 1 Jan 2026
Venkatasubramani Anuroop Venkateswaran, Ichinose Toshiharu, Forne Ignasi, Snyder Nathaniel W, Tanimoto Hiromu, Peleg Shahaf, Imhof Axel
Abstract excerpt
The body temperature of Drosophila melanogaster depends on the extrinsic temperature. Numerous studies show that environmental temperature influences metabolism, lifespan, and starvation resilience. We have previously shown that Chameau (Chm), a MYST-domain acetyltransferase, promotes aging but also increases starvation resilience. Strikingly, the metabolic increase associated with a 2°C temperature rise was...
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