Article
Mitochondrial β-carbonic anhydrase is a conserved metabolic rheostat for branched-chain amino acid catabolism and metabolic flexibility.
The New phytologist - 1 May 2026
Sharma Naveen, Sharkey Thomas D, Brandizzi Federica
Abstract excerpt
Carbonic anhydrases (CAs) are ubiquitous metalloenzymes that catalyze the reversible hydration of CO2, enabling fundamental processes in organisms across all domains of life. Among all CAs, the role of mitochondrial βCA remains poorly understood. Here, we identify a mitochondrial βCA, βCA6, as a key regulator of branched-chain amino acid (BCAA) catabolism and metabolic flexibility during carbon starvation in...
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