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Article

Diagnostic criteria for NK cell large granular lymphocyte leukemia: validation through a multicentric international study.

Blood advances - 10 Feb 2026

Pastoret Cedric, Yang Jun, Feith David J, Roussel Mikaël, Moignet Aline, Dighe Shubha, Solga Micheal Dimitri, Marchand Tony, Visser Garance, Gasparini Vanessa Rebecca, Teramo Antonella, Zambello Renato, Loughran Thomas P, Lamy Thierry

Abstract excerpt

ABSTRACT: Natural killer (NK) large granular lymphocytic leukemia (LGLL) is a rare lymphoproliferative disorder lacking definitive clonality markers, complicating diagnosis and distinction from reactive NK cell expansions. We previously proposed an NK clonality score with high diagnostic accuracy, but a subset of patients remained unclassified. In this multicenter international study, we refined and validated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41191533
DOI: 10.1182/bloodadvances.2025016509
PMCID: PMC12870763

Genes

CCL22
STAT3
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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