Article
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer.
Molecular oncology - 1 Feb 2026
Siddiqui Marium T, Cottam Matthew A, Mirza Muhammad Bilal, Lewis Keeli B, Ciombor Kristen K, Washington Mary Kay, Idrees Kamran
Abstract excerpt
Metastatic colorectal cancer (mCRC), particularly microsatellite stable (MSS) cases, often exhibits limited responsiveness to immunotherapy, leaving chemotherapy as the primary treatment option. While chemotherapy effectively targets tumor cells, its impact on the broader mutational landscape, including passenger mutations in large genes such as Titin (TTN), remains poorly understood. Passenger mutations,...
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