Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer.

BMC medical genomics - 18 Jun 2014

Shanmugam Vijayalakshmi, Ramanathan Ramesh K, Lavender Nicole A, Sinari Shripad, Chadha Manpreet, Liang Winnie S, Kurdoglu Ahmet, Izatt Tyler, Christoforides Alexis, Benson Hollie, Phillips Lori, Baker Angela, Murray Christopher, Hostetter Galen, Von Hoff Daniel D, Craig David W, Carpten John D

Abstract excerpt

BACKGROUND: The outcome of patients with metastatic colorectal carcinoma (mCRC) following first line therapy is poor, with median survival of less than one year. The purpose of this study was to identify candidate therapeutically targetable somatic events in mCRC patient samples by whole genome sequencing (WGS), so as to obtain targeted treatment strategies for individual patients. METHODS: Four patients were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Silencing
Share to HCT116 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to INDEL Mutation

Share to Molecular Targeted Therapy

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoric Monoester Hydrolases

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24943349
DOI: 10.1186/1755-8794-7-36
PMCID: PMC4074842

Genes

INPPL1
KRAS
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer.PMID 24943349Read ↗

Genomic landscape of treatment refractory metastatic colorectal cancer.Semantic proximity Read ↗

Multigene Panel Next-Generation Sequencing Techniques in the Management of Patients with Metastatic Colorectal Carcinoma: The Way Forward for Personalized Treatment? A Single-Center Experience.Semantic proximity Read ↗

Molecular profiling of metastatic colorectal tumors using next-generation sequencing: a single-institution experience.Semantic proximity Read ↗

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features.Semantic proximity Read ↗

Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites.Semantic proximity Read ↗

Comprehensive Mutation Profiling of Colorectal Cancer Patients With Lung or Liver Metastasis by Targeted Next-Generation Sequencing.Semantic proximity Read ↗

Genomic Landscape, Targeted Therapies, and Mechanisms of Resistance in Molecularly Selected Metastatic Colorectal Cancer Patients.Semantic proximity Read ↗

The genomics of liver metastases from colon and rectal cancer: An Invited Commentary (invitation from Lee Ocuin, MD and Kevin Behrns, MD) for the special issue of "Management of Advanced Primary and Secondary Liver Malignancies".Semantic proximity Read ↗

High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer.Semantic proximity Read ↗

The Role of Multigene Panel Next-Generation Sequencing Techniques in Managing Patients with Metastatic Colorectal CarcinomaSemantic proximity Read ↗

Molecular Profiling in Metastatic Colorectal Cancer.Semantic proximity Read ↗

Genomic Landscape, Targeted Therapies, and Mechanisms of Resistance in Molecularly Selected Metastatic Colorectal Cancer PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.