Article
Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations.
EMBO molecular medicine - 1 Mar 2026
Gan Shiming, Li Yangyang, Yin Lin, Yang Xiaotong, Lou Chen, Li Sisi, Lin Mingde, Li Xin, Xu Wenchao, Zhou Jiaming, Hu Peiran, Yao Zhendong, Yuan Yuan, Sheng Jianzhong, Zhang Chen, Yang Wei, Li Youjiang, Huang Hefeng
Abstract excerpt
Oocyte activation is essential for successful fertilization and subsequent embryonic development. However, only a few disease-causing genes have been associated with sperm-derived oocyte activation failure, and the underlying molecular mechanisms and therapeutic approaches remain largely unknown. Here, we identified pathogenic mutations in HNRNPR from three infertile patients whose partners repeatedly failed to...
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