Article
Comprehensive genomic profiling of breast cancer reveals mutational landscape and the PEEKABOO model: a population-specific assessment tool for predicting germline mutations.
Journal of translational medicine - 4 Nov 2025
Wu Jinbo, Xu Yaqian, Xie Fei, Yang Liu, Li Huan, Liu Miao, Yang Houpu, Wang Chaobin, Peng Yuan, Yang Yang, Du Wei, Wang Shu
Abstract excerpt
BACKGROUND: Germline mutations in cancer-predisposition genes are critical for clinical risk assessment and therapeutic decisions in breast cancer, yet large-scale genomic studies and population-specific tools remain limited for Asian populations. METHODS: In this prospective clinic-based cohort study, 2700 unselected Chinese breast cancer patients underwent germline sequencing for single nucleotide variations,...
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