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Article

Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome.

The Journal of clinical investigation - 3 Nov 2025

Tefft Kristy, Wang Amy, Reinstein Zachary Z, Zhang Yue, Pillai Arundhati, Hwang Sunghee, Ng Spencer, Cho Raymond J, Cheng Jeffrey B, Kuang Fei Li, King Brett, Choi Jaehyuk

Abstract excerpt

With cell-by-cell mapping, we charted immune cells in lymphocytic-variant hypereosinophilic syndrome, found drug targets, and showed targeted therapy removed disease-causing cells and eased symptoms.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41178717
DOI: 10.1172/JCI190853
PMCID: PMC12578380

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