Article
CYP2C8 rs11572080 and CYP3A4 rs2740574 risk genotypes in paclitaxel-treated premenopausal breast cancer patients.
Scientific reports - 4 Apr 2024
Attia Hanaa R M, Kamel Mahmoud M, Ayoub Dina F, Abd El-Aziz Shereen H, Abdel Wahed Mai M, El-Fattah Safa N Abd, Ablel-Monem Mahmoud A, Rabah Thanaa M, Helal Amany, Ibrahim Mona Hamed
Abstract excerpt
Breast cancer (BC) is the most prevalent malignancy in women globally. At time of diagnosis, premenopausal BC is considered more aggressive and harder to treat than postmenopausal cases. Cytochrome P450 (CYP) enzymes are responsible for phase I of estrogen metabolism and thus, they are prominently involved in the pathogenesis of BC. Moreover, CYP subfamily 2C and 3A play a pivotal role in the metabolism of taxane...
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