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Article

Cross-Trait Genome-Wide Association Study Identifies Shared Genetic Risk Loci Between COPD and Five Autoimmune Diseases.

International journal of chronic obstructive pulmonary disease - 1 Jan 2025

Wen Huilan, Zhang Runan, Zhong Bin, Liu Huan, Liu Chunhua

Abstract excerpt

Background: Chronic obstructive pulmonary disease (COPD) frequently co-occurs with autoimmune diseases (ADs), yet their shared genetic basis remains incompletely understood. This study aimed to evaluate genetic correlations between COPD and seven ADs and identify shared genetic risk loci underlying this comorbidity. Methods: We integrated summary statistics from large-scale genome-wide association studies (GWAS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40917930
DOI: 10.2147/COPD.S533401
PMCID: PMC12409340

Genes

MAPK3
ORMDL3
GMPPB
GSDMB
PGAP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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