Genetic susceptibility and metabolic pathways linking oral health to metabolic dysfunction-associated steatotic liver disease.

Abstract excerpt

BACKGROUND: Emerging evidence indicates that oral health and metabolic dysfunction-associated steatotic liver disease (MASLD) may be interconnected through shared genetic and metabolic pathways. However, the specific mechanisms underlying this association remains poorly understood. METHODS: This population-based study included 478,000 participants from the UK Biobank (mean age: 56.5 years; 54.4% females). The...

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• Genetic Risk Score
• Mediation Analysis
• Metabolic Networks and Pathways
• Non-alcoholic Fatty Liver Disease
• Periodontal Index