Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls.

Investigative ophthalmology & visual science - 1 Oct 2025

Gorski Mathias, Grunin Michelle, Herold Janina M, Fröhlich Benedikt, Behr Merle, Wheeler Nicholas, Bush William S, Song Yeunjoo E, Zhu Xiaofeng, Blanton Susan H, Pericak-Vance Margaret A, Heid Iris M, Haines Jonathan L

Abstract excerpt

Purpose: In 2016, the International Age-related Macular Degeneration Genomics Consortium analyzed data from approximately 50,000 individuals (IAMDGC 1.0) and identified 52 variants across 34 loci associated with advanced AMD (adAMD) in individuals of European ancestry and did not include diverse ancestries, fine-mapping per ancestry, or a predictive model with/without the contributions of one lead genetic risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Complement Factor H

Share to Genome-Wide Association Study

Share to Macular Degeneration

Share to Polymorphism, Single Nucleotide

Share to Population Groups

Source

Open in PubMed Open full text

Identifiers

PMID: 41159651
DOI: 10.1167/iovs.66.13.51
PMCID: PMC12577769

Genes

CFH
ARMS2
CPN1
HTRA1
SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls.PMID 41159651Read ↗

Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.Semantic proximity Read ↗

Distinctive cross-ancestry genetic architecture for age-related macular degenerationSemantic proximity Read ↗

Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration.Semantic proximity Read ↗

Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration.Semantic proximity Read ↗

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.Semantic proximity Read ↗

Whole genome sequencing of 4,787 individuals identifies gene-based rare variants in age-related macular degeneration.Semantic proximity Read ↗

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced diseaseSemantic proximity Read ↗

Whole exome sequencing of extreme age-related macular degeneration phenotypes.Semantic proximity Read ↗

A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 (AREDS2) Report No. 14.Semantic proximity Read ↗

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.Semantic proximity Read ↗

Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.Semantic proximity Read ↗

Common and rare genetic risk variants in age-related macular degeneration and genetic risk score in the Coimbra eye study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.