Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration.

Investigative ophthalmology & visual science - 1 Nov 2023

Acar Ilhan E, Galesloot Tessel E, Luhmann Ulrich F O, Fauser Sascha, Gayán Javier, den Hollander Anneke I, Nogoceke Everson

Abstract excerpt

Purpose: To identify associations of common, low-frequency, and rare variants with advanced age-related macular degeneration (AMD) using whole genome sequencing (WGS). Methods: WGS data were obtained for 2123 advanced AMD patients (participants of clinical trials for advanced AMD) and 2704 controls (participants of clinical trials for asthma [N = 2518] and Alzheimer's disease [N = 186]), and joint genotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Complement Factor H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Macular Degeneration

Share to Membrane Proteins

Share to Nerve Tissue Proteins

Share to Polymorphism, Single Nucleotide

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 37975850
DOI: 10.1167/iovs.64.14.24
PMCID: PMC10664724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration.PMID 37975850Read ↗

Whole genome sequencing of 4,787 individuals identifies gene-based rare variants in age-related macular degeneration.Semantic proximity Read ↗

Whole exome sequencing of extreme age-related macular degeneration phenotypes.Semantic proximity Read ↗

Family-based exome sequencing identifies rare coding variants in age-related macular degeneration.Semantic proximity Read ↗

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.Semantic proximity Read ↗

Rare predicted loss-of-function and damaging missense variants in CFHR5 associate with protection from age-related macular degeneration.Semantic proximity Read ↗

Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls.Semantic proximity Read ↗

Highly penetrant alleles in age-related macular degeneration.Semantic proximity Read ↗

The Effect of Genetic Variants Associated With Age-Related Macular Degeneration Varies With Age.Semantic proximity Read ↗

Comparison of risk allele frequencies of single nucleotide polymorphisms associated with age-related macular degeneration in different ethnic groups.Semantic proximity Read ↗

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.Semantic proximity Read ↗

Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†.Semantic proximity Read ↗

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.