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Article

Integrated machine learning survival framework for consensus modeling in a large multicenter cohort of NSCLC resistant to aumolertinib.

Scientific reports - 28 Oct 2025

Wu Xiao, Lu Yang, Li Yongping, Zhu Annan, Wang Tingting, Su Fang, Wang Zishu, Chen Yongxia, Song Guolei

Abstract excerpt

Patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations often benefit from third-generation tyrosine kinase inhibitors (TKIs), such as aumolertinib (AUM). However, the development of drug resistance significantly limits the clinical efficacy of AUM. To address this, we established an in vitro model of AUM-resistant cell lines and performed RNA...

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Identifiers

PMID: 41152375
DOI: 10.1038/s41598-025-20159-7
PMCID: PMC12569189

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EGFR

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