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Article

Association of IFNL4 and IFITM3 Genetic Variants with Susceptibility to HCV-Related Liver Cirrhosis and Hepatocellular Carcinoma.

Asian Pacific journal of cancer prevention : APJCP - 1 Oct 2025

Osman Enas Ahmed, Mohamed Marwa Ahmed, Abbas Rania M, Badran Ethar Mokhtar, Aly Heba I, Madbouly Medhat M, Khanany Farida M

Abstract excerpt

OBJECTIVE: To ascertain the possible association of IFITM3 rs12252 and IFNL4 rs12979860 genetic polymorphisms with cirrhosis and HCC in chronic HCV-infected patients. METHODS: Genetic variations were assessed in this case-control study using TaqMan real-time polymerase chain reaction (RT-PCR) in 1350 subjects: 450 healthy controls, 450 cirrhosis patients, and 450 patients with HCC. RESULTS: The genotyping of the...

Topics

Genetic Predisposition to Disease
Liver Cirrhosis
Carcinoma, Hepatocellular
Hepatitis C, Chronic
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukins

Interferon Lambda

Membrane Proteins

RNA-Binding Proteins

Case-Control Studies

Polymorphism, Single Nucleotide

Genotyping Techniques

Humans

Male

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 41148623
DOI: 10.31557/APJCP.2025.26.10.3805
PMCID: PMC12906777

Genes

IFITM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41148623-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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