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Enhanced discrimination of Clostridioides difficile transmission using whole-genome sequencing and in silico multi-locus variable number tandem repeat analysis.

Microbiology spectrum - 2 Dec 2025

Sundermann Alexander J, Mills Emma G, Rangachar Srinivasa Vatsala, Griffith Marissa P, Ereifej Deena, Waggle Kady D, Raabe Nathan J, Snyder Graham M, Van Tyne Daria, Pless Lora Lee, Harrison Lee H

Abstract excerpt

Whole-genome sequencing (WGS) is used to establish genetic relatedness of bacteria and track outbreaks in healthcare settings. While WGS provides sufficient discriminatory power to make inferences about genetic relatedness and transmission for most bacterial species, WGS for Clostridioides difficile often fails to do so, even at low single-nucleotide polymorphism (SNP) differences. Multi-locus variable number...

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PMID: 41143519
DOI: 10.1128/spectrum.03287-24
PMCID: PMC12671157

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