Article
Defining and Evaluating a Core Genome Multilocus Sequence Typing Scheme for Genome-Wide Typing of Clostridium difficile.
Journal of clinical microbiology - 1 Jun 2018
Bletz Stefan, Janezic Sandra, Harmsen Dag, Rupnik Maja, Mellmann Alexander
Abstract excerpt
Clostridium difficile, recently renamed Clostridioides difficile, is the most common cause of antibiotic-associated nosocomial gastrointestinal infections worldwide. To differentiate endogenous infections and transmission events, highly discriminatory subtyping is necessary. Today, methods based on whole-genome sequencing data are increasingly used to subtype bacterial pathogens; however, frequently a...
Topics
- Bacterial Typing Techniques
- Bayes Theorem
- Clostridioides difficile
- Genome, Bacterial
- Genotype
- Humans
- Multilocus Sequence Typing
- Phylogeny
- Whole Genome Sequencing