Kinship Decouple and Phenotype Selection (KDPS): a tool for phenotype-aware decoupling of related subjects.

Abstract excerpt

Relatedness within genomic cohorts is a potential source of bias for many genetic analyses. Existing tools to break relatedness are phenotype-naïve; they indiscriminately remove subjects to break relationship, risking the loss of valuable data, especially in studies targeting uncommon and rare phenotypes. To address this limitation, we developed the Kinship Decouple and Phenotype Selection (KDPS) tool, with a...

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