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Article

Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity.

Science advances - 24 Oct 2025

Villaplana-Velasco Ana, Perrot Nicolas, Hang Yu, Chong Michael, Trucco Emanuele, Mookiah Muthu R K, Nelson Walter, Petch Jeremy, Gerstein Hertzel C, Raina Parminder, Yusuf Salim, Bernabeu Miguel O, Tenesa Albert, Rawlik Konrad, Pare Guillaume, Doney Alexander, Pairo-Castineira Erola, Pigeyre Marie

Abstract excerpt

With the increasing proportion of elderly individuals, understanding biological mechanisms of aging is critical. Retinal vascular complexity, measured as fractal dimension (Df) from fundus photographs, has emerged as a vascular aging indicator. We conducted a genome-wide association study of Df on 74,434 participants from the Canadian Longitudinal Study on Aging, Genetics of Diabetes Audit and Research in Tayside...

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Source

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Identifiers

PMID: 41134885
DOI: 10.1126/sciadv.adu1985
PMCID: PMC12551708

Genes

DAAM1
MMP12

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