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Article

Fine-mapping of retinal vascular complexity loci identifies Notch regulation as a shared mechanism with myocardial infarction outcomes.

Communications biology - 15 May 2023

Villaplana-Velasco Ana, Pigeyre Marie, Engelmann Justin, Rawlik Konrad, Canela-Xandri Oriol, Tochel Claire, Lona-Durazo Frida, Mookiah Muthu Rama Krishnan, Doney Alex, Parra Esteban J, Trucco Emanuele, MacGillivray Tom, Rannikmae Kristiina, Tenesa Albert, Pairo-Castineira Erola, Bernabeu Miguel O

Abstract excerpt

There is increasing evidence that the complexity of the retinal vasculature measured as fractal dimension, Df, might offer earlier insights into the progression of coronary artery disease (CAD) before traditional biomarkers can be detected. This association could be partly explained by a common genetic basis; however, the genetic component of Df is poorly understood. We present a genome-wide association study...

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Share to Coronary Artery Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37188768
DOI: 10.1038/s42003-023-04836-9
PMCID: PMC10185685

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