Article
The Lewis histo-blood group system: molecular analysis of the 59T>G, 508G>A, and 1067T>A polymorphisms in an Amazonian population.
PloS one - 1 Jan 2013
Corvelo Tereza Cristina de Oliveira, de Loiola Rosane do Socorro Pompeu, Aguiar Délia Cristina Figueira, de Matos Gyselly de Cássia Bastos, de Brito Danielle Calado
Abstract excerpt
BACKGROUND: The Lewis (FUT3) gene is responsible for the expression of the Le(a) and Le(b) blood group antigens. The individuals, who not synthesize these antigens have the phenotype Lewis negative, due to the presence of some single nucleotide polymorphisms (SNPs), such as 59T>G, 508G>A and 1067T>A, whose distribution is different in various ethnic groups. Our aim was to verify the frequencies of these SNPs in...
Topics
- Adult
- Female
- Fucosyltransferases
- Genotype
- Humans
- Lewis Blood Group Antigens
- Male
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Young Adult