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Article

Structural and Thermodynamic Insights for Enhanced SNP Detection Using N-Benzimidazole Oligonucleotides.

The journal of physical chemistry. B - 6 Nov 2025

Golyshev Victor M, Morozova Faina V, Berdugin Anton A, Kozyreva Evgenia A, Baranovskaya Elizaveta E, Yushin Ivan I, Lomzov Alexander A

Abstract excerpt

Oligodeoxyribonucleotides bearing N-benzoazole modifications in the phosphate group (PABAO) represent a recently developed class of nucleic acid derivatives with potential in various applications, in particular for SNP detection. This study investigates the physicochemical and substrate properties of DNA/DNA and PABAO/DNA complexes, both perfectly matched and containing a single mismatch near the 3'-end. The...

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Identifiers

PMID: 41128635
DOI: 10.1021/acs.jpcb.5c04047

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