Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mismatch extension of DNA polymerases and high-accuracy single nucleotide polymorphism diagnostics by gold nanoparticle-improved isothermal amplification.

Analytical chemistry - 1 Sept 2015

Chen Feng, Zhao Yue, Fan Chunhai, Zhao Yongxi

Abstract excerpt

Sequence mismatches may induce nonspecific extension reaction, causing false results for SNP diagnostics. Herein, we systematically investigated the impact of various 3'-terminal mismatches on isothermal amplification catalyzed by representative DNA polymerases. Despite their diverse efficiencies depending on types of mismatch and kinds of DNA polymerase, all 12 kinds of single 3'-terminal mismatches induced the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to Cytochrome P-450 CYP2C19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Electrophoresis, Polyacrylamide Gel

Share to Nanoparticles

Share to Nucleic Acid Amplification Techniques

Share to Sequence Alignment

Source

Identifiers

PMID: 26249366
DOI: 10.1021/acs.analchem.5b01545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mismatch extension of DNA polymerases and high-accuracy single nucleotide polymorphism diagnostics by gold nanoparticle-improved isothermal amplification.PMID 26249366Read ↗

Double base mismatches mediated catalytic hairpin assembly for enzyme-free single-base mutation detection: integrating signal recognition and amplification in one.Semantic proximity Read ↗

Label-free optical detection of single-base mismatches by the combination of nuclease and gold nanoparticles.Semantic proximity Read ↗

Concentration-Bias-Free Discrimination of Single Nucleotide Variants Using Isothermal Nucleic Acid Amplification and Mismatch-Guided DNA Assembly.Semantic proximity Read ↗

Accurate and visual discrimination of single-base mismatch by utilization of binary DNA probes in gold nanoparticles-based biosensing strategy.Semantic proximity Read ↗

A bulged-type enzyme-free recognition strategy designed for single nucleotide polymorphisms integrating with label-free electrochemical biosensor.Semantic proximity Read ↗

DNA dangling-end-induced colloidal stabilization of gold nanoparticles for colorimetric single-nucleotide polymorphism genotyping.Semantic proximity Read ↗

Non-cross-linking gold nanoparticle aggregation as a detection method for single-base substitutions.Semantic proximity Read ↗

Amplified single base-pair mismatch detection via aggregation of exonuclease-sheared gold nanoparticles.Semantic proximity Read ↗

Novel biosensing methodologies for improving the detection of single nucleotide polymorphism.Semantic proximity Read ↗

Entropy-Driven Circuit Integrated with Ligases to Regulate DNA-AuNP Network Disintegration for Colorimetric Detection of Single Nucleotide Polymorphisms.Semantic proximity Read ↗

Invading stacking primer: A trigger for high-efficiency isothermal amplification reaction with superior selectivity for detecting microRNA variants.Semantic proximity Read ↗

Simple and accurate visual detection of single nucleotide polymorphism based on colloidal gold nucleic acid strip biosensor and primer-specific PCR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.