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Article

Health effects of loss of function variants in gene targets for Alzheimer's disease prevention.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Dec 2025

Ma Yuan, Zhang Allena, Asri Sabrina, Curtis David

Abstract excerpt

Treatments for Alzheimer’s disease (AD) have to date met with limited success but potentially promising approaches involve attempting to reduce expression of one of the genes coding for key proteins involved in AD pathogenesis. Potential targets for such interventions include APOE, APP and MAPT but there is little published evidence to help assess whether reducing expression of one of these genes might cause...

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Aged
Alzheimer Disease
Amyloid beta-Protein Precursor
Apolipoproteins E
MAPT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

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Open in PubMed Open full text

Identifiers

PMID: 41123760
DOI: 10.1007/s10072-025-08578-w
PMCID: PMC12678446

Genes

APOE
APP
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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