Article
Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study.
Genes, brain, and behavior - 1 Oct 2025
Shinoda Genki, Obara Taku, Takahashi Ippei, Ohseto Hisashi, Kawaguchi Chikana, Narita Akira, Noda Aoi, Murakami Keiko, Orui Masatsugu, Ishikuro Mami, Taira Makiko, Sakamoto Hiroshi, Nakaya Naoki, Hozawa Atsushi, Fuse Nobuo, Tamiya Gen, Mugikura Shunji, Suzuki Kyoko, Kuriyama Shinichi
Abstract excerpt
Heritability of cognitive function is estimated to be 50%-80%. Genome-wide association studies (GWASs) have identified multiple cognitive function-associated loci, primarily in the European population. However, those in Asian populations, particularly in individuals of Japanese ancestry, remain limited. Hence, this GWAS aimed to identify cognitive function-associated genetic loci in elderly individuals of...
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