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Article

Proline 110 is necessary for maintaining a compact helical arrangement in caveolin-1.

Biophysical chemistry - 1 Jan 2026

Brandmier Katrina, Glover Kerney Jebrell

Abstract excerpt

Caveolin-1 (Cav1) is an integral membrane protein essential for the formation of caveolae, plasma microdomains implicated in signal transduction and mechanoprotection. Cav1 is comprised of three major alpha helices, but the topology these helices adopt remains unclear. Proline 110 is located between helix 1 and helix 2, and is hypothesized to enable Cav1 to adopt an intramembrane turn crucial for the cytosolic...

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PMID: 41106301
DOI: 10.1016/j.bpc.2025.107535

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