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Article

Targeting the c-MET signaling pathway for cancer therapy

12 Jun 2008

Abstract excerpt

BACKGROUND: In many human cancers, c-MET is activated via receptor overexpression, amplification, mutation and/or a ligand-dependent autocrine/paracrine loop. These biochemical and genetic abnormalities have been correlated with poor clinical outcomes and drug resistance in cancer patients. Preclinical studies suggest that targeting aberrant c-MET signaling could be an attractive therapy in cancer, but this...

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PMID: 18549337
DOI: 10.1517/13543784.17.7.997

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