Article
The genetics of Parkinson disease: Implications for neurological care.
Nature clinical practice. Neurology - 1 Mar 2006
Klein Christine, Schlossmacher Michael G
Abstract excerpt
The identification of single genes linked to heritable forms of Parkinson disease (PD) has challenged the previously held view of a nongenetic etiology for this progressive movement disorder. Detailed analyses of individuals with mutations in SNCA, Parkin, PINK1, DJ1 or LRRK2 have greatly advanced our knowledge of preclinical and clinical, morphological, and pathological changes in PD. These genetic breakthroughs...
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