Article
POLR3A mutations cause nucleolus abnormalities and aberrant telomerase RNA metabolism in induced pluripotent stem cells from Wiedemann-Rautenstrauch premature aging syndrome patient.
Biogerontology - 13 Oct 2025
Orlova Evgeniya A, Abdyev Vepa K, Morgunova Valeriya, Schukina Anna A, Kungurtseva Anastasiia L, Vasiluev Peter A, Tabakov Vyacheslav Y, Vorontsova Ekaterina O, Zinina Elena V, Izvolskaia Marina, Minzhenkova Marina E, Vitebskaya Alisa V, Kalmykova Alla
Abstract excerpt
Induced pluripotent stem cells (iPSCs) derived from patients with premature aging disorders are widely regarded as a foundation for both the study of fundamental aging mechanisms and preclinical testing of anti-aging therapies. The most well-studied is Hutchinson-Gilford progeria syndrome (HGPS), which is caused by a lamin A gene mutation. Comparing the progeroid phenotype in cell models of distinct premature...
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