Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy.

doi:10.1016/j.kint.2025.08.035

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Article

Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy.

Kidney international - 1 Jan 2026

Benigni Ariela, Daina Erica, Löffler-Wirth Henry, Piras Rossella, Rigoldi Miriam, Schmidt Maria, Carrara Camillo, Donadelli Roberta, Imanifard Zahra, Mele Caterina, Alberti Marta, Marasà Maddalena, Martinatto Carolina, Bresin Elena, Gamba Sara, Quadri Lisa, Nanchen Giliane, Vivarelli Marina, Emma Francesco, La Manna Gaetano, Vidal Enrico, Pasini Andrea, Ranghino Andrea, Donati Gabriele, Verrina Enrico, Angeletti Andrea, Brunori Giuliano, Giordano Mario, Alberici Federico, Maggiore Umberto, Malgieri Gabriele, Remuzzi Giuseppe, Breno Matteo, Noris Marina

Abstract excerpt

INTRODUCTION: Membranoproliferative glomerulonephritis (MPGN) is currently stratified into complement C3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). However, classification is subject to continued debate. METHODS: Here, we applied hierarchical clustering to a much larger cohort of patients with C3G/IC-MPGN (295 individuals), extensively characterized for genetic and autoimmune complement...

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Topics

Humans
Glomerulonephritis, Membranoproliferative

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Complement C3

Cluster Analysis

Antigen-Antibody Complex

Male

Female

Adult

Middle Aged

Complement Activation

Complement C3 Nephritic Factor

Kidney Glomerulus

Phenotype

Biopsy

Source

Open in PubMed

Identifiers

PMID: 41076080
DOI: 10.1016/j.kint.2025.08.035

Genes

Variants

Provenance

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