Article
Identification of susceptibility loci using a novel murine model for triple-negative breast cancer.
G3 (Bethesda, Md.) - 4 Feb 2026
Kim Minjeong, McGrath Logan G, Mustafa Zeid T, Eugin Simon Samson, Pervaiz Naveed, Grey Emily W, Joseph Sydney C, Korba Emily, Marathe Sandesh J, Bohm Margaret S, Ramesh Arvind V, Mahajan Sidharth S, Bohl Casey J, Prins Pjotr, Read Robert W, Holt Jeremiah R, Hayes D Neil, Lu Lu, Williams Robert W, Sipe Laura M, Ashbrook David G, Makowski Liza
Abstract excerpt
Triple-negative breast cancer (TNBC) is the deadliest subtype of breast cancer (BC) with few targeted therapies. To identify novel genetic modifiers of TNBC, we created a murine model incorporating high levels of genetic and phenotypic diversity. C3(1)-T-antigen ("C3Tag") mice, which develop spontaneous basal-like TNBC tumors, were systematically crossed with a large set of sequenced BXD recombinant inbred...
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