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Article

DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities

17 Jun 2016

Abstract excerpt

UNLABELLED: : Advances in DNA sequencing technology have created a wealth of information regarding the genomic landscape of prostate cancer. It had been thought that BRCA1 and BRCA2 mutations were associated with only a small fraction of prostate cancer cases. However, recent genomic analysis has revealed that germline or somatic inactivating mutations in BRCA1 or BRCA2, or other genes involved in the homologous...

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PMID: 27317574
DOI: 10.1634/theoncologist.2016-0135

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