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Prostate cancer and PARP inhibitors: progress and challenges

29 Mar 2021

Abstract excerpt

Despite survival improvements achieved over the last two decades, prostate cancer remains lethal at the metastatic castration-resistant stage (mCRPC) and new therapeutic approaches are needed. Germinal and/or somatic alterations of DNA-damage response pathway genes are found in a substantial number of patients with advanced prostate cancers, mainly of poor prognosis. Such alterations induce a dependency for...

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PMID: 33781305
DOI: 10.1186/s13045-021-01061-x

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