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Article

Targeting DNA Damage Response in Prostate and Breast Cancer

4 Nov 2020

Abstract excerpt

Steroid hormone signaling induces vast gene expression programs which necessitate the local formation of transcription factories at regulatory regions and large-scale alterations of the genome architecture to allow communication among distantly related cis-acting regions. This involves major stress at the genomic DNA level. Transcriptionally active regions are generally instable and prone to breakage due to the...

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PMID: 33158305
DOI: 10.3390/ijms21218273

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