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Article

Overexpression of CCK Neuropeptide in brain is linked to ZBTB20 mutations: potential diagnostic relevance in glioblastoma.

BMC medical genomics - 7 Oct 2025

Dakal Tikam Chand, Sharma Narendra Kumar, Yadav Vikas, Kumar Abhishek, Chen Peng, Schmidt-Wolf Ingo, Maciaczyk Jarek, Sharma Amit

Abstract excerpt

Glioblastoma (GBM), the most malignant central nervous system cancer, has a median survival rate of 14–16 months. GBM patients have a poor prognosis despite rigorous multi-modal treatments like surgical resection, chemotherapy, and radiation. A systematic bioinformatics analysis of GXA gene expression datasets showed thirty-three overexpressed genes in GBM that were enriched in neuroactive ligand receptor...

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Source

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Identifiers

PMID: 41057875
DOI: 10.1186/s12920-025-02218-0
PMCID: PMC12505565

Genes

CCK
ZBTB20
IDH1
APLN
BRAF
CNR1
GRIA4
PDYN
SETD2
TERT
VGF

Provenance

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