Article

IGF2BP1 induces high-risk neuroblastoma and forms a druggable feedforward loop with MYCN promoting 17q oncogene expression

2023-03-21

Abstract excerpt

<h4>Background</h4> Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma relapse, emphasizing the need of novel drug targets and therapeutic strategies. In neuroblastoma, chromosomal gains at chromosome 17q, including IGF2BP1 , and MYCN amplification at chromosome 2p are associated with adverse outcome. Recent,...

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Literature Corpus work: 4a2b94d4-6cd4-510e-b1e5-b92ef465ba8c
DOI: 10.1101/2023.03.18.533148

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