Article
Three-dimensional cardiovascular imaging-genetics: a mass univariate framework.
Bioinformatics (Oxford, England) - 1 Jan 2018
Biffi Carlo, de Marvao Antonio, Attard Mark I, Dawes Timothy J W, Whiffin Nicola, Bai Wenjia, Shi Wenzhe, Francis Catherine, Meyer Hannah, Buchan Rachel, Cook Stuart A, Rueckert Daniel, O'Regan Declan P
Abstract excerpt
Motivation: Left ventricular (LV) hypertrophy is a strong predictor of cardiovascular outcomes, but its genetic regulation remains largely unexplained. Conventional phenotyping relies on manual calculation of LV mass and wall thickness, but advanced cardiac image analysis presents an opportunity for high-throughput mapping of genotype-phenotype associations in three dimensions (3D). Results: High-resolution...
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