Article
Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth.
Molecular cancer therapeutics - 4 Feb 2026
Ahmad Mudassier, Alvi Sahir Sultan, Ahsan Haider, Perez Carlos, Massey Andrew, Kashyap Vivek K, Chauhan Neeraj, Anning Emmanuel, Tripathi Manish K, Kim Dae J, Sahoo Nirakar, Oraby Tamer, Yallapu Murali M, Khan Mohammad Moshahid, Sebastian Manu M, Chauhan Subhash C, Hafeez Bilal B
Abstract excerpt
Dysregulated ribosome biogenesis and p53 mutations are known to play oncogenic roles in various cancers, including pancreatic cancer. In this study, we demonstrated the therapeutic potential of BMH-21, a pharmacologic inhibitor of RNA polymerase I, against pancreatic cancer by uncovering a novel molecular mechanism involving RPA194-mediated ubiquitination of mutant p53 without affecting the ubiquitination of...
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