Article
Mediterranean diet, metabolic signature, genetic predisposition, and risk of rheumatoid arthritis: a large-scale population-based prospective cohort study.
The American journal of clinical nutrition - 1 Dec 2025
Song Xin, Ma Xiaofeng, Yang Bin, Zhang Di, Zou Yanqiu, Lei Bowen, Xiang Rong, Zhao Xunying, Qu Yang, Zheng Sirui, Yu Ting, Zhou Jinyu, Han Tao, Zhong Yangdan, Xia Maoyao, Alfredsson Lars, Leander Karin, Fan Mengyu, Jiang Xia
Abstract excerpt
BACKGROUND: Although the Mediterranean (MED) diet has been associated with reduced rheumatoid arthritis (RA) risk, the underlying metabolic mechanisms and the role of genetic susceptibility in this relationship remain unknown. OBJECTIVES: This study aims to identify a metabolic signature linked to the MED diet and examine its association with the risk of RA, while accounting for genetic predispositions. METHODS:...
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- Humans
- Arthritis, Rheumatoid
- Diet, Mediterranean
- Female
- Male