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Circulating Metabolite Signatures Linking Physical Activity to Inflammatory Bowel Disease Risk and Interactions With Genetic Susceptibility.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jul 2026

He Zixuan, Sun Yuhao, Huang Hanyi, Fu Tian, Yuan Shuai, Larsson Susanna C, Wolk Alicja, Ludvigsson Jonas F, Wang Xiaoyan, Li Xue, Burisch Johan, Magro Fernando, Bai Yu, Chen Jie

Abstract excerpt

BACKGROUND & AIMS: Recent studies have demonstrated the protective effect of physical activity on incident inflammatory bowel diseases (IBD), but the underlying mechanism remains unclear, and whether it interacts with genetic susceptibility is still unknown. METHODS: The study was conducted leveraging large-scale circulating metabolomics data from 2 prospective cohorts, the UK Biobank study and the Whitehall II...

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PMID: 41297737
DOI: 10.1016/j.cgh.2025.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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