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Article

Identification of non-functional allelic variant of CYP1A2 in dogs.

Pharmacogenetics - 1 Nov 2004

Mise Masashi, Hashizume Takanori, Matsumoto Satoshi, Terauchi Yoshiaki, Fujii Toshihiko

Abstract excerpt

OBJECTIVES: Recently, we reported that AC-3933, a novel cognitive enhancer, is polymorphically hydroxylated in beagle dogs and that dogs could be phenotyped as extensive metabolizers (EM) or poor metabolizers (PM). AC-3933 polymorphic hydroxylation is caused by polymorphic expression of CYP1A2 protein in dog liver. METHODS: In order to clarify the mechanism of polymorphic expression of CYP1A2 protein in beagle...

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PMID: 15564884
DOI: 10.1097/00008571-200411000-00008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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