Article
A distinctive immunophenotypic signature in thrombocytopenic septic patients: platelet and neutrophil dysregulations as key contributors to disease severity.
Journal of thrombosis and haemostasis : JTH - 1 Jan 2026
Mulet Maria, Osuna-Gómez Rubén, Martínez-España Laura, Artesero Iris, Duch-Llorach Pol, Vera-Artázcoz Paula, Torrens-Sonet Maria, Rodríguez-Farré Núria, Vilalta Noelia, Abril-Gamboa Andrés, Seres Montserrat, Cantó Elisabet, Àngels Ortiz Ma, López-Contreras Joaquín, Vidal Silvia
Abstract excerpt
BACKGROUND: Thrombocytopenia is frequently associated with increased mortality in sepsis; however, the underlying immunological mechanisms remain poorly understood. OBJECTIVES: This study characterizes molecular and phenotypic changes associated with thrombocytopenia in sepsis, focusing on platelets (PLTs), neutrophils, and their interactions, and evaluates their contributions to poor outcomes. METHODS: Blood...
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