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Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population-based cohort study.

Aging cell - 1 Apr 2025

Zhao Hao, Zhang Xuening, Li Yanzhi, Wang Wanxin, Lai Wenjian, Zhang Wenjing, Kang Kai, Zhong Xiali, Guo Lan

Abstract excerpt

The global aging population raises concerns about heart failure (HF), yet its association with accelerated biological age (BA) remains inadequately understood. We aimed to examine the longitudinal association between BA acceleration and incident HF risk, assess its modifying effect on genetic susceptibility, and how much BA acceleration mediates the impact of modifiable health behaviors on incident HF. We...

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Identifiers

PMID: 39663608
DOI: 10.1111/acel.14430
PMCID: PMC11984684

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