Article
Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka.
Malaria journal - 9 Mar 2007
Schousboe Mette L, Rajakaruna Rupika S, Salanti Ali, Hapuarachchi Hapuarachchige C, Galappaththy Gawrie N L, Bygbjerg Ib C, Amerasinghe Priyanie H, Konradsen Flemming, Alifrangis Michael
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the Plasmodium vivax dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pvdhps) genes cause parasite resistance to the antifolate drug combination, sulphadoxine/pyrimethamine (SP). Monitoring these SNPs provide insights into the level of drug pressure caused by SP use and presumably other antifolate drugs. In Sri Lanka, chloroquine (CQ) with...
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