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Article

Detection of PIK3CA Mutations in Anal Dysplasia.

The Journal of surgical research - 1 Nov 2025

Johnson Hillary R, Dietmann Elise C, Praska Corinne E, Dennison Kirsten L, McGregor Stephanie M, Suter William, Leverson Glen, Murtaza Muhammed, Carchman Evie H

Abstract excerpt

INTRODUCTION: The incidence of anal cancer is increasing despite screening and treatment options for anal dysplasia, the precursor to anal cancer. Once anal dysplasia is identified, predicting which patients are at the highest risk of progressing to anal cancer remains challenging, as there are no molecular biomarkers for risk stratification. The most common mutation in anal cancer affects the catalytic subunit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41033178
DOI: 10.1016/j.jss.2025.09.003
PMCID: PMC12494155

Genes

PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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