A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

doi:10.1038/s41416-018-0049-2

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Article

A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

British journal of cancer - 1 May 2018

Herfs Michael, Roncarati Patrick, Koopmansch Benjamin, Peulen Olivier, Bruyere Diane, Lebeau Alizee, Hendrick Elodie, Hubert Pascale, Poncin Aurelie, Penny William, Piazzon Nathalie, Monnien Franck, Guenat David, Mougin Christiane, Prétet Jean-Luc, Vuitton Lucine, Segers Karin, Lambert Frederic, Bours Vincent, de Leval Laurence, Valmary-Degano Severine, Quick Charles M, Crum Christopher P, Delvenne Philippe

Abstract excerpt

BACKGROUND: Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be developed. The present article aimed at addressing this information gap by in-depth characterising the anal glandular neoplasms at the histologic,...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Anus Neoplasms
B7-H1 Antigen
ErbB Receptors
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Humans

Inflammation

Kaplan-Meier Estimate

Lymphocytes, Tumor-Infiltrating

Male

Middle Aged

Mutation

Precision Medicine

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 29700411
DOI: 10.1038/s41416-018-0049-2
PMCID: PMC5959925

Genes

EGFR
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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